Endothelin 1 (swine, human)
同義詞:內(nèi)皮縮血管肽 1 (豬,人)
分子量:2491.90
分子式:C109H159N25O32S5
CAS 號(hào):117399-94-7
三字母:Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
單字母:CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
產(chǎn)品描述:
Endothelin 1 (swine, human) 是具有人和豬內(nèi)皮素1序列的合成肽,是有效的內(nèi)源性血管收縮劑。Endothelin 1 通過兩種類型受體ETA和ETB發(fā)揮作用。
體外研究:
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion。