PAR-4 Agonist Peptide, amide TFA
同義詞:PAR-4-AP TFA; AY-NH2 TFA
分子量:794.82
分子式:C36H49F3N8O9
CAS 號:1228078-65-6
三字母:Ala-Tyr-Pro-Gly-Lys-Phe-NH2
單字母:AYPGKF-NH2
產(chǎn)品描述:
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) 是一種蛋白酶激活受體-4 (PAR-4) 激動劑,對 PAR-1 或 PAR-2 都沒有作用,且其作用會被 PAR-4 拮抗劑阻斷。
體內(nèi)研究:
Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)。