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181477-43-0
瀏覽量:25 | 2024/6/11 15:37:28

褪黑素(Met¹⁸⁶)-Melanocyte Protein PMEL 17 (185-193) 


編號:143583

CAS號:181477-43-0

三字母:H2N-Ile-Met-Asp-Gln-Val-Pro-Phe-Ser-Val-OH

描 述:Modified sequence of the gp100 epitope gp(209-217) ITDQVPFSV, in which a methionine replaced the natural threonine at position 2, bound to the HLA-A2 molecule with greater affinity than the unmodified peptide and was shown to have an increased ability to generate melanoma-reactive cytotoxic T lymphocytes (CTLs) in vitro when used for sensitization of peripheral blood mononuclear cells. IMDQVPFSV hold promise for the development of novel cancer immunotherapies.

gp100表位gp(209-217) ITDQVPFSV的修飾序列,其中蛋氨酸取代了2號位置的天然蘇氨酸,與未修飾的肽相比,以更大的親和力結(jié)合到HLA-A2分子上,并且在體外用于外周血單核細(xì)胞致敏時,顯示出提高了產(chǎn)生黑色素瘤反應(yīng)性細(xì)胞毒性T淋巴細(xì)胞(ctl)的能力。IMDQVPFSV有望開發(fā)新的癌癥免疫療法。
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