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WL47
瀏覽量:16 | 2024/6/28 16:00:03

WL47 TFA


產(chǎn)品描述:

WL47 TFA 是一種高親和力的 cavolin-1 (CAV1) ligand (Kd=23 nM),是一種有效的 CAV1寡聚體破壞劑。WL47 TFA 對(duì)CAV1的選擇性高于BSA、酪蛋白和 HEWL。WL47 TFA 比原始 T20 (HY-P0052) 親本序列長(zhǎng)度小80%,可用于caveolin-1功能的研究。


分子量:1942.32
分子式:C82H131N24F3O29S4
三字母:Lys-Leu-Arg-Met-Trp-Ser-Cys-Cys-Ser-Trp-Met-Arg-Leu-Lys

單字母:KLRMWSCCSWMRLK


Caveolin-1 (CAV) is a monotonic membrane protein, 22 kDa, it penetrates only one leaflet of the lipid bilayer, and both the N- and C-termini remain on the cytoplasmic side. Multiple copies of CAV oligomerize can form high molecular weight complexes that bend the membrane inward to form invaginations, termed “caveolae,” of 50-100 nm in diameter.
T20 is a 36 amino acid peptide derived from gp41 and blocks HIV viral fusion with CD4+ T-cells. WL47 is 80% smaller in length and has 7500-fold greater affinity than the original T20 parent sequence.
In vitro, Demonstrating WL47 activity with CAV oligomers and a method for measuring the degree of oligomerization. A variant of CAV (CAV(FLV)) that spontaneously oligomerizes to form CAV nanoparticles with diameters is used to examine deoligomerization by WL47. WL47 effectively disrupts these nanoparticles, but it does not disrupt oligomerization in the presence of a reducing agent, this demonstating that WL47 function requires dimerization by disulfide bond

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