Cortagine
產(chǎn)品描述：
Cortagine 是一種選擇性的促腎上腺皮質(zhì)激素釋放因子受體亞型1(CRF1) 激動(dòng)劑，對(duì) rCRF1 的 EC50 為 2.6 nM。Cortagine 在小鼠模型中具有抗焦慮和抗抑郁作用。
體外研究：
Cortagine inhibits rCRF1 (EC50=0.18 nM) and mCRF2β (EC50=16 nM) in transfected HEK-293 cells
體內(nèi)研究：
Cortagine (30, 100, 300 ng; i.c.v.) significantly decreases the percent time spent in the open arms and number of open arm entries of the elevated plus-maze (EPM) test in nine-week-old male C57BL/6J mice。
分子量：4442.06
Formula：C192H323N55O63S
單字母：Pyr-GPPISIDLSLELLREVLEMERAEQLAQQAANNRLLLDTA-NH2
三字母：Pyr-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Glu-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ala-NH2
