Laminin Pentapeptide(929-933)
編號(hào)：158449
CAS號(hào)：110590-64-2
三字母：H2N-Tyr-Ile-Gly-Ser-Arg-OH
描 述：The pentapeptide YIGSR located within domain III of the laminin B1 chain, represents a major receptor binding site in laminin. By competing with laminin for the cell surface receptor, the short peptide is able to inhibit cell attachment to basement membranes, thus preventing the formation of tumor metastases. YIGSR also promotes tumor cell migration and, moreover, mediates the adhesion of a variety of epithelial cells to laminin.
五肽 YIGSR 位于層粘連蛋白 B1 鏈的域 III 內(nèi)，代表層粘連蛋白中的主要受體結(jié)合位點(diǎn)。通過與層粘連蛋白競(jìng)爭(zhēng)細(xì)胞表面受體，短肽能夠抑制細(xì)胞對(duì)基底膜的附著，從而防止腫瘤轉(zhuǎn)移的形成。YIGSR 還促進(jìn)腫瘤細(xì)胞遷移，此外，還介導(dǎo)多種上皮細(xì)胞與層粘連蛋白的粘附
