Colivelin TFA
分子量：2759.12
分子式：C119H206N32O35.C2HF3O2
CAS 號：2803948-60-7
單字母：SALLRSIPAPAGASRLLLLTGEIDLP
產(chǎn)品描述：
Colivelin TFA 是一種具有大腦通透性的神經(jīng)保護(hù)肽 (neuroprotective peptide)，是 STAT3 的有效激活劑。Coliveli 通過激活 STAT3 在體外抑制神經(jīng)元死亡。Colivelin TFA 對神經(jīng)毒性、Aβ 沉積,神經(jīng)元細(xì)胞凋亡，在神經(jīng)退行性疾病顯示出長期有利的影響。Colivelin TFA 可用于阿爾茨海默病和缺血性腦損傷的相關(guān)研究。
體外研究:
Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Aβ1-43 at a concentration of 100 fm, and keep its neuroprotective action at or above the levels of 1 nm.
Colivelin-induced neuroprotection occurs via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN.
Colivelin reverses caspase3, Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition.
Colivelin (50 µg/mL, 4 hours) significantly increases the p-STAT3 protein levels in BV-2 cells.
體內(nèi)研究:
Colivelin(intracerebroventricular administration; 10 pmol/3 μl; 3 weeks) suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, in addition, it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42.
Colivelin (intraperitoneal administration; 1.4, 7, or 35 nM/0.21mL; on the Y-maze testday) suppresses memory impairment caused by 3-quinuclidinyl benzilateand restricts functional memory deficit.
Colivelin (intraperitoneal injection; 1 mg/kg; 14 days) results in improved motor and cognitive function with time by performance of mNSS, rotarod, and corner turning test.It also reduces lesion volume and improves neurological deficits after MCAO
