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664334-36-5
2024/5/10 14:48:18

Motixafortide 


同義詞:BKT140 (4-fluorobenzoyl); BL-8040; TF14016

分子量:2159.52
分子式:C97H144FN33O19S2
CAS 號:664334-36-5
三字母:{4-Fluorobenzoyl}-Arg-Arg-{2-Naph-Ala}-Cys-Tyr-{Cit}-Lys-{d-Lys}-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys13)

單字母:{4-Fluorobenzoyl}-RR-{2-Naph-Ala}-CY-{Cit}-K-{d-Lys}-PYR-{Cit}-CR-NH2 (Disulfide bridge: Cys4-Cys13)


產(chǎn)品描述:

Motixafortide (BKT140 4-fluorobenzoyl) 是一種新型的CXCR4拮抗劑,IC50約為1 nM。


體外研究:

Motixafortide (BKT140) displays selective toxicity toward AmL and MM cells. Treatment with Motixafortide (BKT140) can overcome IL-6 dependent proliferation and survival of ARH77 MM cells. Motixafortide (BKT140) specifically triggers CXCR4-dependent cell death in leukemia and MM cells. Motixafortide (BKT140) stimulates apoptotic cell death in leukemia and MM cells。


體內(nèi)研究:

Subcutaneous injections of Motixafortide (BKT140) significantly reduces, in a dose-dependent manner, the growth of human acute myeloid leukemia and multiple myeloma xenografts. Tumors from animals treated with Motixafortide (BKT140) are smaller in size and weights, had larger necrotic areas and high apoptotic scores。

上篇: 77739-21-0
下篇: α-CGRP (mouse, rat) (TFA)
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