Atosiban acetate
同義詞:醋酸阿托西班
分子量:1054.24
分子式:C45H71N11O14S2
CAS 號:914453-95-5
產(chǎn)品描述:
Atosiban acetate (RW22164 acetate;RWJ22164 acetate) 是一種九肽,競爭性的加壓素/催產(chǎn)素受體 (vasopressin/oxytocin receptor) 拮抗劑,也是一種脫氨基催產(chǎn)素類似物。Atosiban acetate 是一種主要的宮縮抑制劑,可用于自發(fā)早產(chǎn)的研究。
體外研究:
Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua。