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MOG peptide (35-55) 

分子量：2580.97
分子式：C118H178N36O28S
CAS 號(hào)：2022956-48-3
單字母：MEVGWYRSPFSRVVHLYRNGK-NH2

產(chǎn)品描述：

MOG peptide (35-55) 是髓鞘少突膠質(zhì)細(xì)胞糖蛋白 (MOG) 免疫原肽的 35-55 片段。MOG peptide (35-55) 特異性作用于 CD4+ T 細(xì)胞，能夠誘導(dǎo)實(shí)驗(yàn)性自身免疫性腦脊髓炎 (EAE) 動(dòng)物模型。

體外研究：

The expanded CD4+ T cells are largely specific for the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide 35-55 (MOG35-55), while clonally expanded CD8+ T cells were non-responsive to myelin peptides or proteins。

體內(nèi)研究：

MOG peptide (35-55) (3 mg/mL for 0.1 mL; s.c.; single dose) results active induction of experimental autoimmune encephalomyelitis (EAE) in mice.
MOG peptide (35-55) (200 μg; s.c.; single dose) induces a increasing concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice。