A 71915
產(chǎn)品描述:
A 71915 是一種具有高效、競爭性的 natriuretic peptide receptor A (ANP, NPRA) 拮抗劑 (pKi= 9.18). A71915 的劑量依賴性取代ANP,Ki為0.65 nM。A71915 (pA2= 9.48) 對大鼠ANP誘導的 NB-OK-1 細胞產(chǎn)生cGMP的作用。
體外研究:
A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay.
A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right.
體內(nèi)研究:
A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching。
A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased
分子量:1613.95
分子式:C69H116N26O15S2
CAS 號:132956-87-7
三字母:Arg-Cys-{Cha}-Gly-Gly-Arg-Ile-Asp-Arg-Ile-{d-Tic}-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13)
單字母:RC-{Cha}-GGRIDRI-{d-Tic}-RC-NH2 (Disulfide bridge: Cys2-Cys13)